Enhancing accrual to clinical trials of adolescents and young adults with cancer

Pediatr Blood Cancer. 2018 Sep;65(9):e27233. doi: 10.1002/pbc.27233. Epub 2018 May 11.

Abstract

Underrepresentation of young people in cancer research is an international phenomenon and may contribute to poorer outcomes. We sought to identify systematically tested interventions and strategies to improve recruitment. The review identified 13 papers. The following four themes emerged: trial availability/regulatory factors; service configuration/place-of-care factors; recruitment methods and developmental factors specific to young people. We could not identify any studies that had employed prospective interventions to improve recruitment. Without available research studies in which to garner data on adolescents and young adults, we will always be constrained in our ability to provide evidence based care with resultant limitations on our ability to improve outcomes.

Keywords: adolescents; clinical trial; recruitment; research; young adults.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adolescent
  • Clinical Trials as Topic* / economics
  • Clinical Trials as Topic* / legislation & jurisprudence
  • Health Services Accessibility
  • Humans
  • Life Style
  • Neoplasms / epidemiology
  • Neoplasms / therapy*
  • Patient Selection*
  • Psychology, Adolescent
  • Research Design
  • Young Adult