Atherosclerosis Is an Epigenetic Disease

Trends Endocrinol Metab. 2018 Nov;29(11):739-742. doi: 10.1016/j.tem.2018.04.007. Epub 2018 May 10.

Abstract

Atherosclerosis is a chronic inflammatory and lipid-depository disease that eventually leads to acute cardiovascular events. Emerging evidence supports that epigenetic processes such as DNA methylation, histone modification, and noncoding RNAs play an important role in plaque progression and vulnerability, highlighting the therapeutic potential of epigenetic drugs in cardiovascular therapeutics.

Keywords: DNA methylation; atherosclerosis; epigenetics; histone modification; therapeutics.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Atherosclerosis* / drug therapy
  • Atherosclerosis* / genetics
  • Atherosclerosis* / metabolism
  • DNA Methylation / genetics*
  • Enzyme Inhibitors / therapeutic use*
  • Epigenesis, Genetic / genetics*
  • Histones / metabolism*
  • Humans

Substances

  • Enzyme Inhibitors
  • Histones