Abstract
Seven patients suffering from prostatic cancer were treated with a slow-release D-Trp-6-LHRH preparation for a period of 24-32 months. LH, FSH, PRL and testosterone levels were evaluated before and at the end of treatment and then 40 days later. Baseline and GnRH-, TRH-, and HCG-stimulated hormonal values decreased after treatment. The possibility that a long-term treatment with GnRH analogues induces a sustained suppression of pituitary and testicular function is suggested.
MeSH terms
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Aged
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Aged, 80 and over
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / therapeutic use*
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Delayed-Action Preparations
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Follicle Stimulating Hormone / blood*
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Gonadotropin-Releasing Hormone / administration & dosage
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Gonadotropin-Releasing Hormone / analogs & derivatives*
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Gonadotropin-Releasing Hormone / therapeutic use
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Humans
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Luteinizing Hormone / blood*
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Male
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Middle Aged
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Prolactin / blood*
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Prostatic Neoplasms / blood
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Prostatic Neoplasms / drug therapy*
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Prostatic Neoplasms / physiopathology
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Testosterone / blood*
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Triptorelin Pamoate
Substances
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Antineoplastic Agents
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Delayed-Action Preparations
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Triptorelin Pamoate
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Gonadotropin-Releasing Hormone
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Testosterone
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Prolactin
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Luteinizing Hormone
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Follicle Stimulating Hormone