Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort

Charlotte Jackson; Jo Southern; Ajit Lalvani; Francis Drobniewski; Chris J Griffiths; Marc Lipman; Graham H Bothamley; Jonathan J Deeks; Ambreen Imran; Onn Min Kon; Sithembinkosi Mpofu; Vladyslav Nikolayevskyy; Melanie Rees-Roberts; Alice Sitch; Saranya Sridhar; Chuen-Yan Tsou; Hilary Whitworth; Ibrahim Abubakar

doi:10.1136/thoraxjnl-2017-211124

Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort

Thorax. 2019 Jan;74(1):91-94. doi: 10.1136/thoraxjnl-2017-211124. Epub 2018 May 15.

Authors

Charlotte Jackson¹, Jo Southern², Ajit Lalvani³, Francis Drobniewski^{3

4}, Chris J Griffiths⁵, Marc Lipman^{6

7}, Graham H Bothamley⁸, Jonathan J Deeks^{9

10}, Ambreen Imran², Onn Min Kon^{11

12}, Sithembinkosi Mpofu², Vladyslav Nikolayevskyy^{3

4

13}, Melanie Rees-Roberts³, Alice Sitch⁹, Saranya Sridhar³, Chuen-Yan Tsou⁴, Hilary Whitworth^{3

14}, Ibrahim Abubakar¹

Affiliations

¹ Institute for Global Health, University College London, London, UK.
² TB Section, Public Health England, London, UK.
³ Department of Medicine, Imperial College London, London, UK.
⁴ National Mycobacterium Reference Laboratory, Public Health England, London, UK.
⁵ Centre for Primary Care and Public Health, Queen Mary University of London, London, UK.
⁶ Respiratory & HIV Medicine, Royal Free London NHS Foundation Trust, London, UK.
⁷ UCL Respiratory, Division of Medicine, University College London, London, UK.
⁸ Respiratory Medicine, Homerton University Hospital NHS Foundation Trust, London, UK.
⁹ Test Evaluation Group, Institute for Applied Health Research, University of Birmingham, Birmingham, UK.
¹⁰ National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, UK.
¹¹ Respiratory Medicine, Imperial College Healthcare NHS Trust, London, UK.
¹² National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK.
¹³ Blizard Institute, Queen Mary University of London, London, UK.
¹⁴ Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.

PMID: 29764958
DOI: 10.1136/thoraxjnl-2017-211124

Abstract

We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). Binomial regression with a log link was used to estimate crude and adjusted prevalence ratios (PRs) and 95% CIs for the relationship between diabetes mellitus (DM) and LTBI. Adjusted for age, sex, ethnicity, body mass index and the presence of other immunocompromising conditions, DM was associated with a 15% higher prevalence of LTBI (adjusted PR=1.15, 95% CI 1.02 to 1.30, p=0.025). TRIAL REGISTRATION NUMBER: PREDICT is registered on clinicaltrials.gov (NCT01162265).

Keywords: clinical epidemiology; tuberculosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Cross-Sectional Studies
Diabetes Mellitus / epidemiology*
Female
Humans
Interferon-gamma Release Tests
Latent Tuberculosis / diagnosis
Latent Tuberculosis / epidemiology*
Male
Middle Aged
Prevalence
United Kingdom / epidemiology
Young Adult

Associated data

ClinicalTrials.gov/NCT01162265

Abstract

Publication types

MeSH terms

Associated data

Grants and funding