Trained Microglia Trigger Memory Loss

Iva Lelios; Melanie Greter

doi:10.1016/j.immuni.2018.04.033

Trained Microglia Trigger Memory Loss

Immunity. 2018 May 15;48(5):849-851. doi: 10.1016/j.immuni.2018.04.033.

Authors

Iva Lelios¹, Melanie Greter²

Affiliations

¹ Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
² Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland. Electronic address: [email protected].

PMID: 29768172
DOI: 10.1016/j.immuni.2018.04.033

Abstract

Innate immune training is a recently described mechanism that allows innate cells to recollect a previous inflammatory episode. In a recent issue of Nature, Wendeln et al. (2018) show that peripheral inflammation can alter long-term microglia function, influencing neuropathology later in life.

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MeSH terms

Brain
Humans
Immunologic Memory*
Inflammation
Memory Disorders
Microglia*