Ataxin-2 Is Droppin' Some Knowledge

Lindsay A Becker; Aaron D Gitler

doi:10.1016/j.neuron.2018.05.002

Ataxin-2 Is Droppin' Some Knowledge

Neuron. 2018 May 16;98(4):673-675. doi: 10.1016/j.neuron.2018.05.002.

Authors

Lindsay A Becker¹, Aaron D Gitler²

Affiliations

¹ Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Neurosciences Graduate Program, Stanford University School of Medicine, Stanford, CA 94305, USA.
² Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: [email protected].

PMID: 29772196
DOI: 10.1016/j.neuron.2018.05.002

Abstract

Ataxin-2 is an RNA-binding protein involved in translation regulation and mutated in neurodegenerative diseases, including ALS. In this issue of Neuron, Bakthavachalu et al. (2018) demonstrate that higher-order ataxin-2 RNA/protein assemblies are necessary for both translation-dependent learning and ALS-associated neurodegeneration in Drosophila.

Keywords: ALS; Ataxin-2; RNP granules; liquid-liquid phase separation; translational control.

Publication types

Comment

MeSH terms

Amyotrophic Lateral Sclerosis* / genetics
Animals
Ataxin-2* / genetics
DNA-Binding Proteins
Disease Models, Animal
Drosophila
Drosophila Proteins / genetics
Memory, Long-Term
Nerve Tissue Proteins

Substances

Ataxin-2
DNA-Binding Proteins
Nerve Tissue Proteins
Drosophila Proteins

Grants and funding

R01 DC003896/DC/NIDCD NIH HHS/United States