Quickening: Translational design of resorbable synthetic vascular grafts

Biomaterials. 2018 Aug:173:71-86. doi: 10.1016/j.biomaterials.2018.05.006. Epub 2018 May 5.

Abstract

Traditional tissue-engineered vascular grafts have yet to gain wide clinical use. The difficulty of scaling production of these cell- or biologic-based products has hindered commercialization. In situ tissue engineering bypasses such logistical challenges by using acellular resorbable scaffolds. Upon implant, the scaffolds become remodeled by host cells. This review describes the scientific and translational advantages of acellular, synthetic vascular grafts. It surveys in vivo results obtained with acellular synthetics over their fifty years of technological development. Finally, it discusses emerging principles, highlights strategic considerations for designers, and identifies questions needing additional research.

Keywords: Biodegradable; Degradable vascular graft; Host remodeling; In situ tissue engineering.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry
  • Blood Vessel Prosthesis*
  • Cell Adhesion
  • Cell Proliferation
  • Extracellular Matrix / metabolism
  • Humans
  • Myocytes, Smooth Muscle / cytology
  • Myocytes, Smooth Muscle / metabolism
  • Polymers / chemistry
  • Tissue Scaffolds / chemistry*
  • Vascular Patency

Substances

  • Biocompatible Materials
  • Polymers