Endothelin Receptor Type A-Expressing Cell Population in the Inflow Tract Contributes to Chamber Formation

Rieko Asai; Yuichiro Arima; Daiki Seya; Ki-Sung Kim; Yumiko Kawamura; Yukiko Kurihara; Sachiko Miyagawa-Tomita; Hiroki Kurihara

doi:10.1007/978-4-431-54628-3_40

Endothelin Receptor Type A-Expressing Cell Population in the Inflow Tract Contributes to Chamber Formation

Review

In: Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology [Internet]. Tokyo: Springer; 2016. Chapter 40.

2016 Jun 25.

Authors

Rieko Asai^{1

2}, Yuichiro Arima², Daiki Seya², Ki-Sung Kim², Yumiko Kawamura², Yukiko Kurihara², Sachiko Miyagawa-Tomita¹, Hiroki Kurihara²

Book Editors

Toshio Nakanishi¹, Roger R. Markwald², H.Scott Baldwin³, Bradley B. Keller⁴, Deepak Srivastava⁵, Hiroyuki Yamagishi⁶

Affiliations

¹ Division of Cardiovascular Development and Differentiation, Medical Research Institute, Department of Pediatric Cardiology, Tokyo Women’s Medical University, Tokyo, 162-8666, Japan
² Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan

Book Affiliations

¹ Department of Pediatric Cardiology, Tokyo Women's Medical University, Tokyo, Japan
² Cardiovascular Developmental Biology Center, Medical University of South Carolina Clemson University, Charleston, South Carolina, USA
³ Department of Pediatrics (Cardiology), Vanderbilt University, Nashville, Tennessee, USA
⁴ Pediatrics, Pharmacology and Toxicology, and Bioengineering, University of Louisville, Louisville, Kentucky, USA
⁵ Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
⁶ Pediatrics, Division of Pediatric Cardiology, Keio University School of Medicine, Tokyo, Japan

Excerpt

The mammals and birds have four chambered hearts. The current models show the majority of myocardial cells derive from the first and second heart field, however, little is known regarding how heart field subpopulations contribute to specific regions in the heart. In this study, we revealed that the early Ednra-positive population in the inflow tract region contributes to the chamber myocardium by mouse-chick chimera and CreERT2/loxP lineage tracing system.

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