Inositol Trisphosphate Receptors in the Vascular Development

Keiko Uchida; Maki Nakazawa; Chihiro Yamagishi; Katsuhiko Mikoshiba; Hiroyuki Yamagishi

doi:10.1007/978-4-431-54628-3_32

Inositol Trisphosphate Receptors in the Vascular Development

Review

In: Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology [Internet]. Tokyo: Springer; 2016. Chapter 32.

2016 Jun 25.

Authors

Keiko Uchida^{1

2}, Maki Nakazawa¹, Chihiro Yamagishi¹, Katsuhiko Mikoshiba^{3

4}, Hiroyuki Yamagishi¹

Book Editors

Toshio Nakanishi¹, Roger R. Markwald², H.Scott Baldwin³, Bradley B. Keller⁴, Deepak Srivastava⁵, Hiroyuki Yamagishi⁶

Affiliations

¹ Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan
² Health Center, Keio University, 4-1-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa, 223-8521, Japan
³ Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Saitama, 351-0198, Japan
⁴ Calcium Oscillation Project, International Cooperative Research Project and Solution-Oriented Research for Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama, 332-0012, Japan

Book Affiliations

¹ Department of Pediatric Cardiology, Tokyo Women's Medical University, Tokyo, Japan
² Cardiovascular Developmental Biology Center, Medical University of South Carolina Clemson University, Charleston, South Carolina, USA
³ Department of Pediatrics (Cardiology), Vanderbilt University, Nashville, Tennessee, USA
⁴ Pediatrics, Pharmacology and Toxicology, and Bioengineering, University of Louisville, Louisville, Kentucky, USA
⁵ Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
⁶ Pediatrics, Division of Pediatric Cardiology, Keio University School of Medicine, Tokyo, Japan

Excerpt

The placental circulation is crucial for the development of mammalian embryos [1]. The labyrinth layer in the placenta is created by extensive villous branching of the trophoblast and vascularization arising from the embryonic mesoderm. In the labyrinth, materials are exchanged between the maternal and embryonic circulation. Recently, we have found that inositol 1,4,5-trisphosphate (IP₃) receptors (IP₃Rs) may be required for the placental vascularization.

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