Rhodium-catalyzed asymmetric hydrogenation of β-branched enamides for the synthesis of β-stereogenic amines

Jian Zhang; Chong Liu; Xingguang Wang; Jianzhong Chen; Zhenfeng Zhang; Wanbin Zhang

doi:10.1039/c8cc02798f

Rhodium-catalyzed asymmetric hydrogenation of β-branched enamides for the synthesis of β-stereogenic amines

Chem Commun (Camb). 2018 Jun 8;54(47):6024-6027. doi: 10.1039/c8cc02798f.

Authors

Jian Zhang¹, Chong Liu, Xingguang Wang, Jianzhong Chen, Zhenfeng Zhang, Wanbin Zhang

Affiliation

¹ Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China. [email protected].

PMID: 29796543
DOI: 10.1039/c8cc02798f

Abstract

Using a rhodium complex of a bisphosphine ligand (R)-SDP, β-branched simple enamides with a (Z)-configuration were hydrogenated to β-stereogenic amines in quantitative yields and with excellent enantioselectivities (88-96% ee).