Abstract
We assessed the efficacy of standard 3-day courses of chloroquine and dihydroartemisinin/piperaquine against Plasmodium vivax malaria. Compared with chloroquine, dihydroartemisinin/piperaquine was faster in clearing asexual P. vivax parasites and blocking human-to-mosquito transmission. This drug combination was also more effective in preventing potential recurrences for >2 months.
Keywords:
Anopheles dirus; Cambodia; DHA/PPQ; Plasmodium vivax; chloroquine; dihydroartemisinin/piperaquine; efficacy; feeding assays; infectivity; malaria; mosquitoes; parasites; therapeutic efficacy; transmission; transmission-blocking efficacy.
Publication types
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Randomized Controlled Trial
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Antimalarials / administration & dosage
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Antimalarials / therapeutic use
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Artemisinins / administration & dosage
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Artemisinins / therapeutic use*
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Chloroquine / administration & dosage
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Chloroquine / therapeutic use*
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Drug Combinations
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Female
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Humans
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Malaria, Vivax / drug therapy*
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Malaria, Vivax / epidemiology
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Malaria, Vivax / parasitology
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Malaria, Vivax / transmission
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Male
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Middle Aged
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Plasmodium vivax / drug effects*
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Quinolines / administration & dosage
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Quinolines / therapeutic use*
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Young Adult
Substances
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Antimalarials
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Artemisinins
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Drug Combinations
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Quinolines
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artenimol
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Chloroquine
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piperaquine