Are We There Yet? How and When Specific Biotechnologies Will Improve Human Health

Elizabeth O'Day; Leticia Hosta-Rigau; Diego A Oyarzún; Hideyuki Okano; Víctor de Lorenzo; Conrad von Kameke; Habiba Alsafar; Cong Cao; Guo-Qiang Chen; Weizhi Ji; Richard J Roberts; Mostafa Ronaghi; Karen Yeung; Feng Zhang; Sang Yup Lee

doi:10.1002/biot.201800195

Are We There Yet? How and When Specific Biotechnologies Will Improve Human Health

Biotechnol J. 2019 Jan;14(1):e1800195. doi: 10.1002/biot.201800195. Epub 2018 Jun 13.

Authors

Elizabeth O'Day^{1

2}, Leticia Hosta-Rigau^{1

3}, Diego A Oyarzún^{1

4

5}, Hideyuki Okano^{1

6}, Víctor de Lorenzo^{1

7}, Conrad von Kameke^{1

8}, Habiba Alsafar^{1

9}, Cong Cao^{1

10}, Guo-Qiang Chen^{1

11}, Weizhi Ji^{1

12}, Richard J Roberts^{1

13}, Mostafa Ronaghi^{1

14}, Karen Yeung^{1

15}, Feng Zhang^{1

16

17

18}, Sang Yup Lee^{1

19

20}

Affiliations

¹ Global Future Council on the Future of Biotechnologies, World Economic Forum, Cologny, CH-1223, Geneva, Switzerland.
² Olaris Therapeutics, Inc., 45 Moulton St., Cambridge, MA, 02138, USA.
³ Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Technical University of Denmark, 2800, Kongens Lyngby, Denmark.
⁴ Department of Mathematics, Imperial College London, London, SW7 2AZ, UK.
⁵ EPSRC Centre for Mathematics of Precision Healthcare, Imperial College London, London, SW7 2AZ, UK.
⁶ Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
⁷ National Center of Biotechnology CSIC, Systems Biology Program, Campus de Cantoblanco, E-28049, Madrid, Spain.
⁸ BioInnovators Europe, Berlin, Germany.
⁹ Khalifa University Center for Biotechnology, Khalifa University, PO Box 127788, Abu Dhabi, United Arab Emirates.
¹⁰ University of Nottingham, 199 East Taikang Road, Ningbo, 315100, China.
¹¹ Center for Synthetic and Systems Biology, MOE Lab for Industrial Biocatalysis, Tsinghua-Peking University Center of Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
¹² Kunming University of Science and Technology, 727 Jingming South Rd. Chenh Gong, Kunming, 650500, Yunnan, China.
¹³ New England Biolabs, 240 County Road, Ipswich, MA, 01938, USA.
¹⁴ Illumina Inc., 5200 Illumina Way, San Diego, CA, 92121, USA.
¹⁵ Law School and School of Computer Science University of Birmingham, Birmingham, UK, B15 2TT.
¹⁶ Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
¹⁷ McGovern Institute for Brain Research at MIT, Cambridge, MA, 02139, USA.
¹⁸ Department of Brain and Cognitive Sciences and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
¹⁹ Department of Chemical and Biomolecular Engineering (BK21 Plus program), Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-Ro, Daejeon, 34141, Republic of Korea.
²⁰ The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet Bygning 220, 2800, Kongens Lyngby, Denmark.

PMID: 29799175
DOI: 10.1002/biot.201800195

Abstract

Patient X: A 67-year-old Caucasian man slips on a patch of ice. He has abrasions to his hands and has sustained significant damage to his hip. At the emergency room, he informs clinicians he takes atorvastatin, metformin, and glimepiride to treat hypertension and Type 2 Diabetes Mellitus (T2DM). X-rays reveal a fractured hip, which will require total hip replacement surgery.

Keywords: biotechnology; gene editing; precision medicine; stem cells; tissue engineering.

Publication types

Review

MeSH terms

Biotechnology / methods*
Gene Editing
Humans
Precision Medicine
Public Health*
Tissue Engineering