A Glutathione-Responsive Short Sequence of Metal-Organic Complex Array

Purnandhu Bose; Toshiaki Takei; Xianglan Li; Takashi Minowa; Rajamani Rajmohan; Pothiappan Vairaprakash; Kentaro Tashiro

doi:10.1002/cbic.201800252

A Glutathione-Responsive Short Sequence of Metal-Organic Complex Array

Chembiochem. 2018 May 28. doi: 10.1002/cbic.201800252. Online ahead of print.

Authors

Purnandhu Bose¹, Toshiaki Takei², Xianglan Li², Takashi Minowa², Rajamani Rajmohan³, Pothiappan Vairaprakash³, Kentaro Tashiro¹

Affiliations

¹ International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
² Nanotechnology Innovation Station, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
³ Department of Chemistry, School of Chemical and Biotechnology, SASTRA Deemed University, Thirumalaisamudram 613 401, Thanjavur, India.

PMID: 29806721
DOI: 10.1002/cbic.201800252

Abstract

A short metal-organic complex array (MOCA) containing a sequence of RPtRRu (1_Cl ) was found to exhibit unique responses to a major biothiol, glutathione (GSH). Upon binding of GSH to 1_Cl , the resultant 1:1 complex (1_GS ) formed nanofibrous assemblies that suggested supramolecular polymerization through the double-salt-bridge structure formation. The binding behavior of this MOCA sequence to calf thymus DNA was also dependent on GSH; a larger conformational change of DNA was observed upon binding with 1_GS , relative to that with 1_Cl .

Keywords: DNA; glutathione; metal-organic complex arrays; metalation; nanostructures; peptides.