Crystal structure of 4-(pyrazin-2-yl)morpholine

Acta Crystallogr E Crystallogr Commun. 2018 Jan 12;74(Pt 2):137-140. doi: 10.1107/S2056989018000312. eCollection 2018 Feb 1.

Abstract

The mol-ecular structure of the title compound, C8H11N3O, is nearly planar despite the chair conformation of the morpholine moiety. In the crystal, the mol-ecules form sheets parallel to the b axis, which are supported by non-classical hydrogen-bonding inter-actions between C-H functionalities and the O atom of morpholine and the 4-N atom of pyrazine, respectively. The title compound crystallizes in the monoclinic space group P21/c with four mol-ecules in the unit cell.

Keywords: Buchwald–Hartwig amination; crystal structure; morpholine; palladium-catalysed reactions; pyrazine.

Grants and funding

This work was funded by Alexander von Humboldt-Stiftung grant 3.4 - IP - DEU/1131213 to Anant R. Kapdi and Carola Schulzke. FP7 Ideas: European Research Council grant 281257 to Carola Schulzke.