Abstract
A hetero-binuclear Ir(iii)-Pt(ii) complex was developed as an antitumor agent. In vitro cytotoxicity results indicated that this complex was effective against cisplatin-resistant tumor cells. Mechanism experiments showed that it can overcome cisplatin resistance by increasing cellular uptake, targeting mitochondria, and inducing cell necrosis.
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cisplatin / pharmacology
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Coordination Complexes / chemical synthesis
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Coordination Complexes / pharmacology*
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Drug Resistance, Neoplasm / drug effects
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Humans
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Iridium / chemistry*
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Mitochondria / metabolism*
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Necrosis / chemically induced*
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Organoplatinum Compounds / chemical synthesis
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Organoplatinum Compounds / pharmacology*
Substances
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Antineoplastic Agents
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Coordination Complexes
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Organoplatinum Compounds
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Iridium
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Cisplatin