Artefactual punctate MLH1 staining can lead to erroneous reporting of isolated PMS2 loss

Histopathology. 2018 Oct;73(4):703-705. doi: 10.1111/his.13663. Epub 2018 Jul 12.

Authors

Bonnie T Niu¹, Rory F L Hammond², Sarah L S Leen², Asma Z Faruqi², Giorgia Trevisan², C Blake Gilks¹, Naveena Singh²

Affiliations

¹ Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada.
² Department of Cellular Pathology Barts Health NHS Trust, London, UK.

PMID: 29852531
DOI: 10.1111/his.13663

No abstract available

MeSH terms

Artifacts
Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis*
Colorectal Neoplasms, Hereditary Nonpolyposis / pathology
Diagnostic Errors
Humans
Mismatch Repair Endonuclease PMS2 / genetics*
MutL Protein Homolog 1 / genetics
MutL Protein Homolog 1 / metabolism*

Substances

MLH1 protein, human
PMS2 protein, human
Mismatch Repair Endonuclease PMS2
MutL Protein Homolog 1