The objective of this study was to assess the usability of RxUniverse, a novel platform that enables health care providers to directly disseminate proven, evidence-based mobile health apps to patients. Among five pilot clinical sites, 40 physicians and front-line providers were trained on the RxUniverse platform. They were educated on the platform's functionality and instructed how to prescribe apps to their patients. The well-validated System Usability Score (SUS) was used to assess the usability of the platform. The adoption goal was set as 100 prescriptions of relevant apps within an 8-week pilot period. Within the pilot period, over 2000 apps were prescribed. Nineteen responses were received from the System Usability Score survey, and the platform received a usability score of 84.2, which is in the 96th percentile across all systems. The pilot study outcomes demonstrate the high adoption and usability of the RxUniverse platform.