Stem-Cell-Derived Cardiomyocytes Grow Up: Start Young and Train Harder

Joshua T Maxwell; Chunhui Xu

doi:10.1016/j.stem.2018.05.011

Stem-Cell-Derived Cardiomyocytes Grow Up: Start Young and Train Harder

Cell Stem Cell. 2018 Jun 1;22(6):790-791. doi: 10.1016/j.stem.2018.05.011.

Authors

Joshua T Maxwell¹, Chunhui Xu²

Affiliations

¹ Division of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
² Division of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. Electronic address: [email protected].

PMID: 29859168
DOI: 10.1016/j.stem.2018.05.011

Abstract

Engineering cardiac tissue that accurately recapitulates adult myocardium is critical for advancing disease modeling, drug screening, and regenerative medicine. Ronaldson-Bouchard et al. report a new strategy for generating cardiac tissues from stem-cell-derived cardiomyocytes that reach a maturation level closer to human adult cardiac structure and function.

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MeSH terms

Drug Evaluation, Preclinical
Humans
Myocardium
Myocytes, Cardiac*
Pluripotent Stem Cells*
Tissue Engineering