The macrophage as a Trojan horse for antisense oligonucleotide delivery

Expert Opin Ther Targets. 2018 Jun;22(6):463-466. doi: 10.1080/14728222.2018.1482279. Epub 2018 Jun 7.

Authors

James S Novak^{1

2

3}, Jyoti K Jaiswal^{1

2

3}, Terence A Partridge^{1

2

3}

Affiliations

¹ a Center for Genetic Medicine Research, Children's Research Institute , Children's National Health System , Washington, DC , USA.
² b Department of Genomics and Precision Medicine , The George Washington University School of Medicine and Health Sciences , Washington, DC , USA.
³ c Department of Pediatrics , The George Washington University School of Medicine and Health Sciences , Washington, DC , USA.

No abstract available

Keywords: Duchenne muscular dystrophy; antisense oligonucleotides; drug delivery; exon skipping; macrophages; satellite cells.

Publication types

Editorial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Gene Transfer Techniques
Genetic Therapy / methods*
Humans
Macrophages / metabolism*
Oligonucleotides, Antisense / administration & dosage*

Substances

Oligonucleotides, Antisense

Grants and funding