Making a Notch in the Evolution of the Human Cortex

Sara Bizzotto; Christopher A Walsh

doi:10.1016/j.devcel.2018.05.015

Making a Notch in the Evolution of the Human Cortex

Dev Cell. 2018 Jun 4;45(5):548-550. doi: 10.1016/j.devcel.2018.05.015.

Authors

Sara Bizzotto¹, Christopher A Walsh²

Affiliations

¹ Division of Genetics and Genomics, Manton Center for Orphan Disease Research, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115, USA; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
² Division of Genetics and Genomics, Manton Center for Orphan Disease Research, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115, USA; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: [email protected].

PMID: 29870717
DOI: 10.1016/j.devcel.2018.05.015

Abstract

The unique structure and function of the human brain ultimately results from the action of evolution on the human genome. In a recent issue of Cell, Fiddes et al. (2018) and Suzuki et al. (2018) describe human-specific NOTCH2 paralogs that enhance neural progenitor proliferation and expand cortical neurogenesis.

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MeSH terms

Brain
Cell Proliferation*
Humans
Neurogenesis*