Exposure to tobacco smoke prenatally and during infancy and risk of hearing impairment among children in Japan: A retrospective cohort study

Paediatr Perinat Epidemiol. 2018 Sep;32(5):430-438. doi: 10.1111/ppe.12477. Epub 2018 Jun 5.

Abstract

Background: Previous studies of the association between tobacco smoke and hearing loss in children are limited, involve small samples and are cross-sectional. We investigated the association of maternal smoking during pregnancy and exposure to tobacco smoke at age 4 months with hearing impairment at age 3 years in children.

Methods: This population-based retrospective cohort study included 50 734 children born between 2004 and 2010 in Kobe City, Japan. Smoking during pregnancy and exposure to tobacco smoke at 4 months was measured using parent-reported questionnaires. Hearing impairment was determined by the whispered voice test.

Results: Of the included children, 3.8% were exposed to smoking only during pregnancy; 3.9% were exposed only to second-hand smoke at 4 months; and 0.9% were exposed to tobacco smoke during pregnancy and at 4 months. The prevalence of hearing impairment at age 3 years was 4.6%. Compared with children not exposed to tobacco smoke prenatally and at 4 months, the risk of hearing impairment was elevated in children exposed to only maternal past smoking during pregnancy (RR 1.26, 95% CI 1.13, 1.40), only second-hand smoke at 4 months (RR 1.30, 95% CI 1.07, 1.56), only smoking during pregnancy (RR 1.68, 95% CI 1.42, 2.00) and smoking during pregnancy and second-hand smoke at 4 months (RR 2.35, 95% CI 1.79, 3.10).

Conclusions: Exposure to tobacco smoke prenatally and postnatally was associated with hearing impairment in children. A prevention of smoking before and during pregnancy and exposure to second-hand smoke postnatally may reduce hearing impairment risk in children.

Keywords: hearing loss; maternal smoking; pregnancy; second-hand smoke; tobacco.

MeSH terms

  • Adolescent
  • Adult
  • Child, Preschool
  • Cross-Sectional Studies
  • Female
  • Hearing Loss / chemically induced*
  • Hearing Loss / epidemiology*
  • Humans
  • Infant
  • Infant, Newborn
  • Japan / epidemiology
  • Male
  • Maternal Exposure / adverse effects*
  • Pregnancy
  • Prenatal Exposure Delayed Effects / epidemiology*
  • Prevalence
  • Retrospective Studies
  • Risk Factors
  • Smoking / adverse effects*
  • Smoking / epidemiology
  • Surveys and Questionnaires
  • Tobacco Smoke Pollution / adverse effects*
  • Young Adult

Substances

  • Tobacco Smoke Pollution