Solute Carrier Family 30 Member 8 Gene 807C/T Polymorphism and Type 2 Diabetes Mellitus in the Chinese Population: A Meta-Analysis Including 6,942 Subjects

Background: Although solute carrier family 30 (zinc transporter) member 8 (SLC30A8) gene 807C/T polymorphism is associated with an increased risk of type 2 diabetes mellitus (T2DM) risk, there remains some inconsistency between individual studies.

Objective: The aim of the study is to explore the relationship between SLC30A8 gene 807C/T polymorphism and T2DM in the Chinese population.

Methods: The current meta-analysis compiles and analyzes the data of 6,942 participants from 10 independent studies. Either a fixed or random-effects model was adopted to evaluate the pooled odds ratio (ORs) and the corresponding 95% confidence interval (95% CI).

Results: A significant association between SLC30A8 gene 807C/T polymorphism and T2DM was found in the Chinese population under allelic (OR: 0.85, 95% CI: 0.80-0.91, P = 7.42 × 10^-7), recessive (OR: 0.52, 95% CI: 0.38-0.72, P = 8.49 × 10^-5), dominant (OR: 2.40, 95% CI: 1.68-3.41, P = 1.30 × 10^-6), homozygous (OR: 0.52, 95% CI: 0.40-0.67, P = 2.90 × 10^-7), heterozygous (OR: 0.79, 95% CI: 0.71-0.88, P = 1.63 × 10^-5), and additive genetic models (OR: 0.73, 95% CI: 0.64-0.83, P = 7.05 × 10^-7).

Conclusion: SLC30A8 gene 807C/T polymorphism was significantly associated with an increased T2DM risk in the Chinese population. Therefore, individuals of Chinese descent with the C allele of SLC30A8 gene 807C/T polymorphism may be more susceptible to developing T2DM, while individuals with the T allele may be protected against T2DM.