A haunted beast: Targeting STAT5BN642H in T-Cell Neoplasia

Ha Thi Thanh Pham; Markus Hengstschläger; Richard Moriggl

doi:10.1080/23723556.2018.1435181

A haunted beast: Targeting STAT5B_N642H in T-Cell Neoplasia

Mol Cell Oncol. 2018 Mar 28;5(3):e1435181. doi: 10.1080/23723556.2018.1435181. eCollection 2018.

Authors

Ha Thi Thanh Pham^{1

2

3}, Markus Hengstschläger³, Richard Moriggl^{1

2

4}

Affiliations

¹ Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
² Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria.
³ Center of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical University of Vienna, Vienna, Austria.
⁴ Medical University of Vienna, Vienna, Austria.

Abstract

The somatic hot spot mutation STAT5B_N642H was found in many T cell leukemia/lymphoma patients. We generated and analyzed a transgenic mouse model with hematopoietic STAT5B_N642H expression that caused aggressive T-cell leukemia/lymphomas. Herein, we discuss the scientific merit of our model and its relevance for pre-clinical studies.

Keywords: Aurora kinase; JAK kinase; STAT5 N642H driver mutation; T-cell neoplasia.

Grants and funding

This work was supported by the by the Austrian Science Fund (FWF) under Grant SFB-F4707-B20 and SFB-F6105.