ETV6-NTRK3 induces aggressive acute lymphoblastic leukemia highly sensitive to selective TRK inhibition

Blood. 2018 Aug 23;132(8):861-865. doi: 10.1182/blood-2018-05-849554. Epub 2018 Jun 7.

Abstract

Publisher's Note: There is a Blood Commentary on this article in this issue.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Crizotinib / pharmacology*
  • Humans
  • Mice
  • Mice, Transgenic
  • Oncogene Proteins, Fusion* / antagonists & inhibitors
  • Oncogene Proteins, Fusion* / genetics
  • Oncogene Proteins, Fusion* / metabolism
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / genetics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / metabolism
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / pathology
  • Protein Kinase Inhibitors / pharmacology*

Substances

  • ETV6-NTRK3 fusion protein, mouse
  • Oncogene Proteins, Fusion
  • Protein Kinase Inhibitors
  • Crizotinib