Hematopoietic cell transplantation for myeloid/NK cell precursor acute leukemia in second remission

Yusuke Noguchi; Daisuke Tomizawa; Haruka Hiroki; Satoshi Miyamoto; Mari Tezuka; Reiji Miyawaki; Mari Tanaka-Kubota; Tubasa Okano; Chika Kobayashi; Noriko Mitsuiki; Yuki Aoki; Kohsuke Imai; Michiko Kajiwara; Hirokazu Kanegane; Tomohiro Morio; Masatoshi Takagi

doi:10.1002/ccr3.1506

Hematopoietic cell transplantation for myeloid/NK cell precursor acute leukemia in second remission

Clin Case Rep. 2018 Apr 10;6(6):1023-1028. doi: 10.1002/ccr3.1506. eCollection 2018 Jun.

Authors

Yusuke Noguchi¹, Daisuke Tomizawa^{1

2}, Haruka Hiroki¹, Satoshi Miyamoto¹, Mari Tezuka^{1

3}, Reiji Miyawaki^{1

4}, Mari Tanaka-Kubota¹, Tubasa Okano¹, Chika Kobayashi¹, Noriko Mitsuiki¹, Yuki Aoki^{1

5}, Kohsuke Imai¹, Michiko Kajiwara⁶, Hirokazu Kanegane¹, Tomohiro Morio¹, Masatoshi Takagi¹

Affiliations

¹ Department of Pediatrics and Developmental Biology Graduate School of Medicine Tokyo Medical and Dental University Yushima 1-5-45, Bunkyo-ku Tokyo Japan.
² Division of Leukemia and Lymphoma Children's Cancer Center National Center for Child Health and Development Okura 2-10-1, Setagaya-ku Tokyo Japan.
³ Department of Pediatrics Ehime Prefectural Central Hospital Kasuga 83 Matsuyama Ehime Japan.
⁴ Department of Pediatrics Matsuyama Red Cross Hospital Bunkyo-cho Matsuyama Ehime Japan.
⁵ Department of Pediatrics Oncology National Cancer Research Center Tsukiji 5-1-1, Chuo-ku Tokyo Japan.
⁶ Department of Transfusion Medicine Graduate School of Medicine Tokyo Medical and Dental University Yushima 1-5-45, Bunkyo-ku Tokyo Japan.

Abstract

Myeloid/natural killer cell precursor acute leukemia (MNKPL) is a rare leukemia subtype characterized by a high incidence of extramedullary infiltration. No appropriate treatment strategy has so far been developed. Acute myelogenous leukemia-type chemotherapy combined with L-Asparaginase is an effective treatment for MNKPL. Hematopoietic cell transplantation is a second option in refractory cases.

Keywords: Hematopoietic cell transplantation; L‐Asparaginase; myeloid/natural killer cell precursor acute leukemia.

Publication types

Case Reports