Toxins that Trash Translation

Mol Cell. 2018 Jun 7;70(5):759-760. doi: 10.1016/j.molcel.2018.05.027. Epub 2018 Jun 7.

Abstract

Culviner and Laub (2018) use RNA-seq and ribosome profiling to determine how MazF inhibits translation in E. coli. Challenging an earlier model, they argue that MazF cleaves mRNA and blocks ribosome biogenesis but does not generate specialized ribosomes that preferentially translate leaderless transcripts.

Publication types

  • Comment

MeSH terms

  • DNA-Binding Proteins
  • Endoribonucleases
  • Escherichia coli / genetics*
  • Escherichia coli Proteins
  • RNA, Messenger*
  • RNA, Ribosomal
  • Ribosomes

Substances

  • DNA-Binding Proteins
  • Escherichia coli Proteins
  • MazF protein, E coli
  • RNA, Messenger
  • RNA, Ribosomal
  • Endoribonucleases