Roseosporol A, the first isolation of a novel sesquiterpenoid from Streptomyces roseosporus

Lina Deng; Rui Wang; Guowei Wang; Mingxu Liu; Zhihua Liao; Guojian Liao; Min Chen

doi:10.1080/14786419.2018.1484457

Roseosporol A, the first isolation of a novel sesquiterpenoid from Streptomyces roseosporus

Nat Prod Res. 2019 Jul;33(14):2038-2043. doi: 10.1080/14786419.2018.1484457. Epub 2018 Jun 11.

Authors

Lina Deng¹, Rui Wang¹, Guowei Wang¹, Mingxu Liu¹, Zhihua Liao², Guojian Liao¹, Min Chen¹

Affiliations

¹ a College of Pharmaceutical Sciences, Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University) , Ministry of Education , Southwest University , Chongqing , P.R. China.
² b School of Life Sciences , Southwest University , Chongqing , P.R. China.

PMID: 29888959
DOI: 10.1080/14786419.2018.1484457

Abstract

A novel sesquiterpenoid, roseosporol A (1), together with 12 known compounds (2-13) were isolated from the ethyl acetate extract of Lsr2-deletion mutant strain of Streptomyces roseosporus. Their structures were determined by spectroscopic methods, including NMR, HRMS, UV, IR and ECD.

Keywords: -deletion; Roseosporol A; sesquiterpenoid.

MeSH terms

Acetates
Molecular Structure
Mutation
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification*
Spectrum Analysis
Streptomyces / chemistry*
Streptomyces / genetics

Substances

Acetates
Sesquiterpenes
ethyl acetate