Abstract
We have biochemically treated (periodate, borohydride, neuraminidase, organic solvents) frozen sections of human pancreas and studied the reactivity of islet-cell-antibody-positive human sera and monoclonal antibodies. The autoantigen of pancreatic sections has the properties of sialic acid containing glycolipid.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antibodies / analysis*
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Antibodies, Monoclonal
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Antigens / analysis*
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Cytoplasm / immunology
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Fluorescent Antibody Technique
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Glycolipids / analysis*
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Humans
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Immunoenzyme Techniques
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Islets of Langerhans / immunology*
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Neuraminidase / metabolism
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Periodic Acid
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Pronase / metabolism
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Sialic Acids / analysis*
Substances
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Antibodies
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Antibodies, Monoclonal
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Antigens
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Glycolipids
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Sialic Acids
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Periodic Acid
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metaperiodate
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Neuraminidase
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Pronase