Rare variants in Fanconi anemia genes are enriched in acute myeloid leukemia

Kyaw Ze Ya Maung; Paul J Leo; Mahmoud Bassal; Debora A Casolari; James X Gray; Sarah C Bray; Stephen Pederson; Deepak Singhal; Saumya E Samaraweera; Tran Nguyen; Gökhan Cildir; Mhairi Marshall; Adam Ewing; Emma L Duncan; Matthew A Brown; Russell Saal; Vinay Tergaonkar; Luen Bik To; Paula Marlton; Devinder Gill; Ian Lewis; Andrew J Deans; Anna L Brown; Richard J D'Andrea; Thomas J Gonda

doi:10.1038/s41408-018-0090-7

Rare variants in Fanconi anemia genes are enriched in acute myeloid leukemia

Blood Cancer J. 2018 Jun 1;8(6):50. doi: 10.1038/s41408-018-0090-7.

Authors

Kyaw Ze Ya Maung^{1

2

3

4}, Paul J Leo⁵, Mahmoud Bassal^{4

6

7}, Debora A Casolari^{2

4

7}, James X Gray^{1

2

3}, Sarah C Bray^{2

4

7}, Stephen Pederson⁸, Deepak Singhal^{2

4

7}, Saumya E Samaraweera^{4

7}, Tran Nguyen^{4

7}, Gökhan Cildir⁴, Mhairi Marshall⁵, Adam Ewing⁹, Emma L Duncan^{5

10

11}, Matthew A Brown⁵, Russell Saal⁵, Vinay Tergaonkar^{4

12}, Luen Bik To^{2

7}, Paula Marlton¹³, Devinder Gill¹³, Ian Lewis^{2

4}, Andrew J Deans¹⁴, Anna L Brown^{4

15}, Richard J D'Andrea^{16

17

18

19}, Thomas J Gonda^{20

21}

Affiliations

¹ Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville, SA, Australia.
² School of Medicine, University of Adelaide, Adelaide, SA, Australia.
³ Department of Haematology and Oncology, The Queen Elizabeth Hospital, Woodville, SA, Australia.
⁴ Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia.
⁵ Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology and University of Queensland Diamantina Institute, Brisbane, QLD, Australia.
⁶ School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia.
⁷ Departments of Haematology, SA Pathology and Royal Adelaide Hospital, Adelaide, SA, Australia.
⁸ Adelaide Bioinformatics, School of Biological Sciences and School of Mathematics, University Of Adelaide, Adelaide, SA, Australia.
⁹ Mater Research Institute, University of Queensland, Brisbane, QLD, Australia.
¹⁰ Department of Endocrinology, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.
¹¹ School of Medicine, University of Queensland, Brisbane, QLD, Australia.
¹² Institute of Molecular and Cell Biology, NUS School of Medicine, Singapore, Singapore.
¹³ Clinical Haematology, Princess Alexandra Hospital Brisbane, Woolloongabba, QLD, Australia.
¹⁴ St Vincent's Institute of Medical Research, Melbourne, VIC, Australia.
¹⁵ Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia.
¹⁶ School of Medicine, University of Adelaide, Adelaide, SA, Australia. [email protected].
¹⁷ Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia. [email protected].
¹⁸ School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia. [email protected].
¹⁹ Departments of Haematology, SA Pathology and Royal Adelaide Hospital, Adelaide, SA, Australia. [email protected].
²⁰ University of South Australia Cancer Research Institute, Adelaide, SA, Australia. [email protected].
²¹ School of Pharmacy, University of Queensland, Brisbane, QLD, Australia. [email protected].

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Fanconi Anemia Complementation Group Proteins / genetics*
Genetic Association Studies*
Genetic Predisposition to Disease*
Genetic Variation*
Genotype
Humans
Leukemia, Myeloid, Acute / diagnosis*
Leukemia, Myeloid, Acute / genetics*
Mutation

Substances

Fanconi Anemia Complementation Group Proteins