Cell Entry of Influenza A Viruses: Sweet Talk between HA and CaV1.2

Markus Hoffmann; Stefan Pöhlmann

doi:10.1016/j.chom.2018.05.019

Cell Entry of Influenza A Viruses: Sweet Talk between HA and Ca_V1.2

Cell Host Microbe. 2018 Jun 13;23(6):697-699. doi: 10.1016/j.chom.2018.05.019.

Authors

Markus Hoffmann¹, Stefan Pöhlmann²

Affiliations

¹ Infection Biology Unit, German Primate Center, 37077 Göttingen, Germany.
² Infection Biology Unit, German Primate Center, 37077 Göttingen, Germany. Electronic address: [email protected].

PMID: 29902433
DOI: 10.1016/j.chom.2018.05.019

Abstract

Influenza A viruses attach to sialic acids on host cells. In this issue of Cell Host & Microbe, Fujioka et al. (2018) show that binding to a specific sialylated cellular protein facilitates infection: engagement of sialic acids linked to the Ca²⁺ channel Ca_V1.2 induces Ca²⁺ oscillations, which promote infectious entry.

Publication types

Comment

MeSH terms

Hemagglutinin Glycoproteins, Influenza Virus*
Influenza A virus*
Receptors, Virus
Sialic Acids

Substances

Hemagglutinin Glycoproteins, Influenza Virus
Receptors, Virus
Sialic Acids