Thermodynamic limits to the stoichiometry of H+ pumping by mitochondrial cytochrome oxidase

M P Murphy; G C Brown; M D Brand

doi:10.1016/0014-5793(85)81204-7

Thermodynamic limits to the stoichiometry of H+ pumping by mitochondrial cytochrome oxidase

FEBS Lett. 1985 Jul 22;187(1):16-20. doi: 10.1016/0014-5793(85)81204-7.

Authors

M P Murphy, G C Brown, M D Brand

PMID: 2991005
DOI: 10.1016/0014-5793(85)81204-7

Abstract

H+/O stoichiometries of 0, 2 and 4 have been proposed for cytochrome oxidase. Here we show that a stoichiometry of 4 is thermodynamically impossible for rat liver cytochrome oxidase under normal conditions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Electron Transport Complex IV / metabolism*
Kinetics
Mathematics
Mitochondria, Liver / enzymology*
Protons
Rats
Thermodynamics

Substances

Protons
Electron Transport Complex IV