Three cases of monoclonal gammopathy of renal significance after kidney transplantation. De novo C3 glomerulopathy

Nefrologia (Engl Ed). 2019 Mar-Apr;39(2):198-201. doi: 10.1016/j.nefro.2018.03.008. Epub 2018 Jun 15.
[Article in English, Spanish]

Abstract

Monoclonal gammopathy of renal significance includes all renal disorders caused by a monoclonal immunoglobulin secreted by a non-malignant B-cell clone. Patients with MGRS do not, by definition, meet criteria for multiple myeloma, with haematological disorders generally considered to be monoclonal gammopathy of undetermined significance. Nevertheless, the renal involvement can be serious and require specific treatment. Monoclonal gammopathy of renal significance is associated with a wide spectrum of disorders, including the recently discovered C3 glomerulopathy. Development of C3 glomerulopathy in the context of monoclonal gammopathy of renal significance after kidney transplantation is uncommon and very few cases have been published to date. We report on three cases of C3 glomerulopathy in the context of de novo monoclonal gammopathy after kidney transplantation.

Keywords: C3 glomerulopathy; Gammapatía monoclonal; Kidney transplant; Monoclonal gammopathy; Nefropatía C3; Trasplante renal.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Complement C3*
  • Female
  • Glomerulonephritis / diagnosis
  • Glomerulonephritis / drug therapy
  • Glomerulonephritis / etiology
  • Humans
  • Kidney Diseases / etiology*
  • Kidney Diseases / immunology
  • Kidney Diseases / surgery
  • Kidney Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Paraproteinemias / complications*
  • Paraproteinemias / immunology
  • Polycystic Kidney Diseases / complications
  • Postoperative Complications / drug therapy
  • Postoperative Complications / etiology*
  • Postoperative Complications / immunology
  • TRPP Cation Channels / genetics

Substances

  • Complement C3
  • TRPP Cation Channels
  • polycystic kidney disease 1 protein