Sulfur from Within: Cytosolic tRNA Thiouridinylation

Joseph J Braymer; Dennis R Winge

doi:10.1016/j.chembiol.2018.06.003

Sulfur from Within: Cytosolic tRNA Thiouridinylation

Cell Chem Biol. 2018 Jun 21;25(6):645-647. doi: 10.1016/j.chembiol.2018.06.003.

Authors

Joseph J Braymer¹, Dennis R Winge²

Affiliations

¹ Philipps-Universität Marburg, Marburg, Germany.
² University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA. Electronic address: [email protected].

PMID: 29932897
DOI: 10.1016/j.chembiol.2018.06.003

Abstract

In this issue of Cell Chemical Biology, Pandey et al. (2018) identified that mitochondrial cysteine desulfurase provides the sulfur species used for tRNA^Lys, tRNA^Glu, and tRNA^Gln thiouridine modification in the cytoplasm. A low-mass sulfur species is exported by the mitochondrial Atm1 transporter and utilized in the thio-modifications.

Publication types

Comment

MeSH terms

Cytosol
Mitochondria*
RNA, Transfer*
Sulfur
Thiouridine

Substances

Thiouridine
Sulfur
RNA, Transfer