3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling

Xuanyi Ma; Justin Liu; Wei Zhu; Min Tang; Natalie Lawrence; Claire Yu; Maling Gou; Shaochen Chen

doi:10.1016/j.addr.2018.06.011

3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling

Adv Drug Deliv Rev. 2018 Jul:132:235-251. doi: 10.1016/j.addr.2018.06.011. Epub 2018 Jun 21.

Authors

Xuanyi Ma¹, Justin Liu², Wei Zhu³, Min Tang³, Natalie Lawrence³, Claire Yu³, Maling Gou⁴, Shaochen Chen⁵

Affiliations

¹ Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
² Materials Science and Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
³ Department of NanoEngineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
⁴ State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, PR China.
⁵ Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Materials Science and Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of NanoEngineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, PR China. Electronic address: [email protected].

Abstract

3D bioprinting is emerging as a promising technology for fabricating complex tissue constructs with tailored biological components and mechanical properties. Recent advances have enabled scientists to precisely position materials and cells to build functional tissue models for in vitro drug screening and disease modeling. This review presents state-of-the-art 3D bioprinting techniques and discusses the choice of cell source and biomaterials for building functional tissue models that can be used for personalized drug screening and disease modeling. In particular, we focus on 3D-bioprinted liver models, cardiac tissues, vascularized constructs, and cancer models for their promising applications in medical research, drug discovery, toxicology, and other pre-clinical studies.

Keywords: 3D printing; Biomaterials; Disease model; Drug screening; In vitro culture; Tissue engineering; Tissue model.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Biomimetic Materials / chemistry
Bioprinting*
Cardiovascular Diseases / pathology*
Drug Evaluation, Preclinical*
Humans
Models, Biological*
Precision Medicine*
Printing, Three-Dimensional*
Tissue Engineering*

Abstract

Publication types

MeSH terms

Grants and funding