Impact of tumor deposits on the prognosis and chemotherapy efficacy in stage III colorectal cancer patients with different lymph node status: A retrospective cohort study in China

Xiao Li; Bang An; Qi Zhao; Jianni Qi; Wenwen Wang; Di Zhang; Zhen Li; Chengyong Qin

doi:10.1016/j.ijsu.2018.06.029

Impact of tumor deposits on the prognosis and chemotherapy efficacy in stage III colorectal cancer patients with different lymph node status: A retrospective cohort study in China

Int J Surg. 2018 Aug:56:188-194. doi: 10.1016/j.ijsu.2018.06.029. Epub 2018 Jun 21.

Authors

Xiao Li¹, Bang An², Qi Zhao¹, Jianni Qi³, Wenwen Wang¹, Di Zhang¹, Zhen Li¹, Chengyong Qin⁴

Affiliations

¹ Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China; Shandong Provincial Engineering and Technological Research Center for Liver Diseases Prevention and Control, Jinan, 250021, China.
² Department of Cardiology, Central Hospital of Zibo, Zibo, 255036, China.
³ Central Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China; Shandong Provincial Engineering and Technological Research Center for Liver Diseases Prevention and Control, Jinan, 250021, China.
⁴ Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China; Shandong Provincial Engineering and Technological Research Center for Liver Diseases Prevention and Control, Jinan, 250021, China. Electronic address: [email protected].

PMID: 29936197
DOI: 10.1016/j.ijsu.2018.06.029

Abstract

Background: The goal was to determine whether tumor deposits (TDs) had effects on the overall survival (OS), cancer-specific survival (CSS), disease-free survival (DFS) and responses to chemotherapy in advanced colorectal cancer (CRC) patients with different lymph node (N) stages.

Materials and methods: The retrospective cohort study recruited 1455 stage III CRC patients diagnosed at a single institution between January 2010 and July 2016. Patients were divided into TDs negative and positive groups. Based on whether they accepted chemotherapy, patients were further divided into chemotherapy and non-chemotherapy groups. Kaplan-Meier methods, univariate and multivariate analyses, and subset analyses based on the N stage were performed to compare the OS, CSS and DFS between different groups.

Results: Multivariate Cox analyses showed that TDs were independent prognostic markers for the OS (adjusted HR = 1.929, 95% CI: 1.339-2.777), CSS (adjusted HR = 1.789, 95% CI: 1.165-2.748) and DFS (adjusted HR = 2.179, 95% CI: 1.612-2.944) in all N stages combined. In addition, subset analyses based on the N stage further demonstrated that TDs were independent risk factors for the OS (P = 0.012), CSS (P = 0.010) and DFS (P < 0.001) in patients with the N1a, 1 b stages, and for the OS (P = 0.023) and DFS (P < 0.001) in patients with the N2a, 2 b stages. Furthermore, the OS, CSS and DFS in the TDs negative group could be extended significantly after the administration of chemotherapy, whereas patients with positive TDs lost the DFS benefit from chemotherapy.

Conclusions: Stage III CRC patients with positive TDs had a poor prognosis, and they did not display a DFS benefit from chemotherapy. TDs had adverse effects on the OS and DFS in patients with the N1a, 1 b and N2a, 2 b stages, providing evidence for the feasibility of the new TNM category method.

Keywords: Colorectal cancer; Positive lymph nodes; Prognosis; TNM staging system; Tumor deposits.

MeSH terms

Adult
Aged
Aged, 80 and over
Antineoplastic Agents / therapeutic use*
China
Colorectal Neoplasms / drug therapy
Colorectal Neoplasms / mortality*
Colorectal Neoplasms / pathology*
Disease-Free Survival
Female
Humans
Lymph Nodes / pathology*
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk Factors
Treatment Outcome

Substances

Antineoplastic Agents