Genetic characterization and therapeutic targeting of MYC-rearranged T cell acute lymphoblastic leukaemia

Br J Haematol. 2019 Apr;185(1):169-174. doi: 10.1111/bjh.15425. Epub 2018 Jun 25.
No abstract available

Keywords: BRD4 inhibition; T cell acute lymphoblastic leukaemia; t(8;14)(q24;q11) translocation.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomarkers, Tumor
  • DNA Copy Number Variations
  • Disease Models, Animal
  • Gene Rearrangement*
  • Genes, myc*
  • Genetic Association Studies
  • Genetic Predisposition to Disease*
  • Humans
  • Mice
  • Molecular Targeted Therapy
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Translocation, Genetic
  • Xenograft Model Antitumor Assays

Substances

  • Biomarkers, Tumor