Abstract
The mutation of the Parkin gene is a cause of familial Parkinson's disease. A growing body of evidence suggests that Parkin also functions as a tumor suppressor. Parkin is an ubiquitin E3 ligase, and plays important roles in a variety of cellular processes implicated in tumorigenesis, including cell cycle, cell proliferation, apoptosis, metastasis, mitophagy and metabolic reprogramming. Here we review the role and mechanism of Parkin in cancer.
Keywords:
Cancer; E3 ubiquitin ligase; Parkin; Parkinson’s disease; Tumor suppressor.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Apoptosis / genetics
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Cell Proliferation / genetics
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Genetic Predisposition to Disease / genetics*
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Humans
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Mitophagy / genetics
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Mutation*
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Neoplasms / genetics
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Neoplasms / metabolism
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Parkinson Disease / genetics*
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Parkinson Disease / metabolism
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Tumor Suppressor Proteins / genetics*
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Tumor Suppressor Proteins / metabolism
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Ubiquitin-Protein Ligases / genetics*
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Ubiquitin-Protein Ligases / metabolism
Substances
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Tumor Suppressor Proteins
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Ubiquitin-Protein Ligases
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parkin protein