Abstract
Phytochemical investigation on the roots of Swietenia macrophylla yielded one new pharagmalin-type limonoid named 2-dehydroxyl-swietephragmin C (1) and one new xanthone, 1,5-dihydroxy-6-methoxy-6',6'-dimethyl-2H-pyrano[2',3':3,2]xanthone (2), in addition to three known compounds. The structures of the new compounds were unambiguously determined by comprehensive spectroscopic methods (NMR, UV, IR, MS), as well as by comparison with the reported data in the literature. Xanthones were reported from Swietenia genus for the first time.
Keywords:
Meliaceae; limonoid; xanthone.
MeSH terms
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Bacteria / drug effects
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Cell Line, Tumor
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Cholinesterase Inhibitors / pharmacology
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Fungi / drug effects
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Glycoside Hydrolase Inhibitors / chemistry
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Glycoside Hydrolase Inhibitors / pharmacology
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Humans
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Limonins / isolation & purification*
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Limonins / pharmacology*
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Magnetic Resonance Spectroscopy
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Meliaceae / chemistry*
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Microbial Sensitivity Tests
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Molecular Structure
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Roots / chemistry*
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Spectrometry, Mass, Electrospray Ionization
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Xanthones / isolation & purification*
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Xanthones / pharmacology*
Substances
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Anti-Infective Agents
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Antineoplastic Agents, Phytogenic
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Cholinesterase Inhibitors
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Glycoside Hydrolase Inhibitors
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Limonins
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Plant Extracts
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Xanthones