From vesicle to cytosol

Elife. 2018 Jun 27:7:e38847. doi: 10.7554/eLife.38847.

Abstract

Drugs called bisphosphonates are used to treat a range of bone diseases, but how do they reach the enzymes that are their target?

Keywords: biochemistry; bone-targeting drugs; cell biology; chemical biology; genome-wide screening; human; lysosomes; mechanism of action; membrane transporter; mouse.

Publication types

  • Comment

MeSH terms

  • Cytosol*
  • Diphosphonates*
  • Nitrogen

Substances

  • Diphosphonates
  • Nitrogen