Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth

Cell Res. 2018 Aug;28(8):862-864. doi: 10.1038/s41422-018-0060-4. Epub 2018 Jun 29.

Authors

Yi Yang¹, Chia-Wei Li¹, Li-Chuan Chan^{1

2}, Yongkun Wei¹, Jung-Mao Hsu¹, Weiya Xia¹, Jong-Ho Cha¹, Junwei Hou¹, Jennifer L Hsu¹, Linlin Sun^{1

3}, Mien-Chie Hung^{4

5}

Affiliations

¹ Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
² Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
³ Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, 30052, China.
⁴ Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. [email protected].
⁵ Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. [email protected].

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Aniline Compounds / pharmacology
Animals
B7-H1 Antigen / immunology*
Benzylidene Compounds / pharmacology
Breast Neoplasms / immunology*
Breast Neoplasms / pathology*
Cell Line, Tumor
Exosomes / drug effects
Exosomes / immunology*
Female
Heterografts
Humans
Immunologic Surveillance*
Macrophages / immunology
Mice
Mice, Inbred BALB C
Mice, Nude
T-Lymphocytes / immunology*
Tumor Microenvironment

Substances

Aniline Compounds
B7-H1 Antigen
Benzylidene Compounds
CD274 protein, human
Cd274 protein, mouse
GW 4869

Grants and funding