Cellular retinol-binding protein in normal and neoplastic human mammary gland

Breast Cancer Res Treat. 1985;6(2):131-6. doi: 10.1007/BF02235744.

Abstract

The concentration of cellular retinol-binding protein (CRBP) was determined in samples of normal and neoplastic mammary gland, using a specific and sensitive radioimmunoassay. The CRBP concentration was significantly higher in neoplastic tissue, but detectable levels were also present in all samples of normal gland. Tubulo-ductal cancers had significantly lower CRBP levels than other cancer types. The CRBP concentration of the neoplastic tissue showed no correlation with the concentration of progesterone or estrogen receptor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / analysis
  • Adult
  • Age Factors
  • Aged
  • Breast / analysis*
  • Breast Neoplasms / analysis*
  • Breast Neoplasms / pathology
  • Carcinoma, Intraductal, Noninfiltrating / analysis
  • Female
  • Humans
  • Middle Aged
  • Receptors, Estrogen / analysis
  • Receptors, Progesterone / analysis
  • Retinol-Binding Proteins / analysis*
  • Retinol-Binding Proteins, Cellular

Substances

  • Receptors, Estrogen
  • Receptors, Progesterone
  • Retinol-Binding Proteins
  • Retinol-Binding Proteins, Cellular