Alleviation of diabetic complications by ginsenoside Rg3-enriched red ginseng extract in western diet-fed LDL-/- mice

Evelyn Saba; Seung-Hyung Kim; Sung-Dae Kim; Sang-Joon Park; Dongmi Kwak; Jun-Hwan Oh; Chae-Kyu Park; Man Hee Rhee

doi:10.1016/j.jgr.2017.04.004

Alleviation of diabetic complications by ginsenoside Rg3-enriched red ginseng extract in western diet-fed LDL^-/- mice

J Ginseng Res. 2018 Jul;42(3):352-355. doi: 10.1016/j.jgr.2017.04.004. Epub 2017 Apr 24.

Authors

Evelyn Saba¹, Seung-Hyung Kim², Sung-Dae Kim³, Sang-Joon Park¹, Dongmi Kwak¹, Jun-Hwan Oh⁴, Chae-Kyu Park⁴, Man Hee Rhee¹

Affiliations

¹ Department of Veterinary Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.
² Institute of Traditional Medicine & Bioscience, Daejeon University, Daejeon, Republic of Korea.
³ Research Center, Dongnam Institute of Radiological and Medical Sciences, Busan, Republic of Korea.
⁴ R&D Headquarters, Korean Ginseng Corporation, Daejeon, Republic of Korea.

Abstract

In this study, we precisely showed how the Rg3-enriched red ginseng extract (Rg3-RGE) lowers glucose, triglyceride, and low-density lipoprotein (LDL) levels in LDL^-/- mice. Aspartate aminotransferase/serum glutamic-oxaloacetic transaminase), alanine aminotransferase /serum glutamate-pyruvate transaminase, and steatohepatitis were found to be reduced, and atheroma formation was inhibited by Rg3-enriched red ginseng extract.

Keywords: Rg3-enriched Korean Red Ginseng extract; antiatheromatic; antidiabetic; antihypercholesterolemic.