Abstract
We studied the biological effects of pluripoietin, a human pluripotent hemopoietic colony-stimulating factor (CSF) purified from the 5637 bladder carcinoma cell line. We found that this human CSF appears to be a unique hemopoietic growth factor, differing from interleukin 3 (IL-3) by virtue of its leukemia differentiating activity in mouse and man, and from mouse granulocyte CSF, which does have differentiation-inducing activity, but lacks pluripoietic activity. In addition, differences from IL-3 were observed in cross-species activity on normal and leukemic cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Carcinoma / metabolism
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Cell Division
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Cell Line
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Cell Survival
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Cell Transformation, Neoplastic / metabolism
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Cell Transformation, Neoplastic / pathology
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Granulocytes / metabolism
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Growth Substances / isolation & purification
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Growth Substances / physiology*
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Hematopoietic Cell Growth Factors
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Hematopoietic Stem Cells / cytology*
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Hematopoietic Stem Cells / pathology
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Humans
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Leukemia / metabolism
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Leukemia / pathology*
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Mice
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Mice, Inbred CBA
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N-Formylmethionine Leucyl-Phenylalanine / metabolism
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Receptors, Formyl Peptide
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Receptors, Immunologic / analysis
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Species Specificity
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Thymidine / metabolism
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Urinary Bladder Neoplasms / metabolism
Substances
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Growth Substances
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Hematopoietic Cell Growth Factors
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Receptors, Formyl Peptide
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Receptors, Immunologic
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N-Formylmethionine Leucyl-Phenylalanine
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Thymidine