Magnetic resonance imaging (MRI) is extensively applied in clinical practice. Segmentation of the MRI brain image is significant to the detection of brain abnormalities. However, owing to the coexistence of intensity inhomogeneity and noise, dividing the MRI brain image into different clusters precisely has become an arduous task. In this paper, an improved possibilistic fuzzy c -means (FCM) method based on a similarity measure is proposed to improve the segmentation performance for MRI brain images. By introducing the new similarity measure, the proposed method is more effective for clustering the data with nonspherical distribution. Besides that, the new similarity measure could alleviate the "cluster-size sensitivity" problem that most FCM-based methods suffer from. Simultaneously, the proposed method could preserve image details as well as suppress image noises via the use of local label information. Experiments conducted on both synthetic and clinical images show that the proposed method is very effective, providing mitigation to the cluster-size sensitivity problem, resistance to noisy images, and applicability to data with more complex distribution.