Objective: To make a preliminery research of comobidity in oral squamous cell carcinoma (OSCC) patients who resides in Beijing area and investigate whether comorbidity affect the surviving rate independently. Compare the similarities and differences between Chinese and foreign OSCC patients. Methods: The medical records of 313 patients who undertaken operation in Peking University Stomatology School from January 2007 to Delember 2009 were retrospectively reviewed. Adult comorbidity evaluation-27 Chinese edition index was used to estimate the comorbidity severity. COX proportional hazards model was used to analyze whether the TNM stage, comobidity, age and gender affected 5-year survival rate. Results: TNM stage and comorbidity have a significant impact on survival rate, the postoperative survival rate decreased significantly with the increasing level of TNM staging and the complexity of comorbidity disease. In this study, the proportion of patients with none, mild, moderate and severe comorbidity diseases was 24%, 48%, 18% and 10%. The five-year survival rates of patients with moderate and severe comorbidity disease were 50% (29/58) and 13% (4/30) respectively. Conclusions: The comorbidity disease information can help assess the overall health of OSCC patients, and it is recommended to improve the clinical staging and overall evaluation of oral cancer patients with comorbidity disease information.
目的： 调查北京地区口腔鳞状细胞癌（oral squamous cell carcinoma，OSCC）患者的并存疾病状况，探讨并存疾病与中外OSCC患者预后的关系，以期为临床提供参考。 方法： 收集2007年1月至2009年12月于北京大学口腔医学院·口腔医院就诊的313例北京地区OSCC患者信息，使用成人并存疾病评价指数27条目中文简体版记录并存疾病情况。使用Cox多元回归分析研究患者年龄、性别、TNM分期、并存疾病分级与术后生存率是否相关。 结果： TNM分期、并存疾病分级对术后生存率是影响OSCC生存率的独立因素。本研究中无、轻度、中度、重度并存疾病患者比例分别为24%、48%、18%、10%。中度与重度并存疾病患者的5年生存率分别为50%（29/58）和13%（4/30）。 结论： 并存疾病信息有助于评估OSCC患者整体健康状况，建议使用并存疾病信息完善OSCC患者的临床分期与整体评估。.
Keywords: Comorbidity; Mouth neoplasms; Neoplasm staging; Prognosis.