Pathogenesis and causations of systemic contact dermatitis

G Ital Dermatol Venereol. 2019 Feb;154(1):42-49. doi: 10.23736/S0392-0488.18.06113-8. Epub 2018 Jul 10.

Abstract

Systemic contact dermatitis (SCD) describes a hypersensitivity reaction following systemic re-exposure of the inciting allergen in previously sensitized individuals. Plants, drugs, and metals are the most common causes of SCD. In individuals with obstinate dermatitis, it is imperative to deliver history-focused patch testing with subsequent avoidance and elimination of the compound.

Publication types

  • Review

MeSH terms

  • Allergens / immunology*
  • Dermatitis, Allergic Contact / diagnosis
  • Dermatitis, Allergic Contact / etiology*
  • Dermatitis, Allergic Contact / immunology
  • Drug Hypersensitivity / diagnosis
  • Drug Hypersensitivity / etiology
  • Drug Hypersensitivity / immunology
  • Humans
  • Metals / adverse effects
  • Metals / immunology
  • Patch Tests / methods*
  • Plants / adverse effects
  • Plants / immunology

Substances

  • Allergens
  • Metals