Piecemeal necrosis is due to the immunologic synapse formation and internalization of intact TCR-MHC II complexes by CD4 T cells

Samuel W French; Jiajie G Lu

doi:10.1016/j.yexmp.2018.07.004

Piecemeal necrosis is due to the immunologic synapse formation and internalization of intact TCR-MHC II complexes by CD4 T cells

Exp Mol Pathol. 2018 Aug;105(1):150-152. doi: 10.1016/j.yexmp.2018.07.004. Epub 2018 Jul 17.

Authors

Samuel W French¹, Jiajie G Lu²

Affiliations

¹ Harbor-UCLA Medical Center, 1000 W. Carson St., Torrance, CA 90500, United States. Electronic address: [email protected].
² Harbor-UCLA Medical Center, 1000 W. Carson St., Torrance, CA 90500, United States.

PMID: 30009774
DOI: 10.1016/j.yexmp.2018.07.004

Abstract

The nature of the immunologic synapse in autoimmune hepatitis is defined. This process involves the T cell receptor (TCR) which binds to the hepatocyte antigen presenting major histocompatibility complex (MHC) on the plasma membrane. This complex is quickly removed from the liver cell and taken into the T cell cytoplasm to be digested by the lysosome. The liver cell is gradually diminished to the point of its total removal by the lymphocytes binding to it.

Keywords: Immunologic synapse; piecemeal necrosis; trogocytosis; troxis necrosis.

MeSH terms

CD4-Positive T-Lymphocytes / immunology*
CD4-Positive T-Lymphocytes / ultrastructure
Hepatitis, Autoimmune / immunology
Hepatitis, Autoimmune / pathology*
Histocompatibility Antigens Class II / immunology*
Humans
Immunological Synapses / immunology*
Necrosis
Receptors, Antigen, T-Cell / immunology*

Substances

Histocompatibility Antigens Class II
Receptors, Antigen, T-Cell