Microwave-Assisted Synthesis of Some Potential Bioactive Imidazolium-Based Room-Temperature Ionic Liquids

Ahmed H Albalawi; Wael S El-Sayed; Ateyatallah Aljuhani; Saud M Almutairi; Nadjet Rezki; Mohamed R Aouad; Mouslim Messali

doi:10.3390/molecules23071727

Microwave-Assisted Synthesis of Some Potential Bioactive Imidazolium-Based Room-Temperature Ionic Liquids

Molecules. 2018 Jul 15;23(7):1727. doi: 10.3390/molecules23071727.

Authors

Ahmed H Albalawi¹, Wael S El-Sayed^{2

3}, Ateyatallah Aljuhani⁴, Saud M Almutairi⁵, Nadjet Rezki^{6

7}, Mohamed R Aouad⁸, Mouslim Messali⁹

Affiliations

¹ Department of Chemistry, Taibah University, Al-Madina Al-Mounawara 30002, Saudi Arabia. [email protected].
² Department of Biology Department, Taibah University, Al-Madina Al-Mounawara 30002, Saudi Arabia. [email protected].
³ Microbiology Department, Faculty of Science, Ain Shams University, Cairo 11566, Egypt. [email protected].
⁴ Department of Chemistry, Taibah University, Al-Madina Al-Mounawara 30002, Saudi Arabia. [email protected].
⁵ King Abdulaziz City for Science and Technology, Riyadh 11442, P.O. Box 6086, Saudi Arabia. [email protected].
⁶ Department of Chemistry, Taibah University, Al-Madina Al-Mounawara 30002, Saudi Arabia. [email protected].
⁷ Laboratoire de Chimie & Electrochimie des Complexes Métalliques (LCECM) USTO-MB, University of Sciences and Technology Mohamed Boudiaf, BP 1505 Oran, El M nouar, Algeria. [email protected].
⁸ Department of Chemistry, Taibah University, Al-Madina Al-Mounawara 30002, Saudi Arabia. [email protected].
⁹ Department of Chemistry, Taibah University, Al-Madina Al-Mounawara 30002, Saudi Arabia. [email protected].

Abstract

An environmentally-friendly and easy synthesis of a series of novel functionalized imidazolium-based ionic liquids (ILs) is described under both the conventional procedure and microwave irradiation. The structures of newly synthesized room-temperature ionic liquids (RTILs) were established by different spectral analyses. All ILs (1⁻14) were screened for their in vitro antimicrobial activity against a panel of clinically isolated bacteria. The results of the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) showed that some of the tested ILs are very promising anti-bacterial agents especially those containing an alkyl chain with a phenyl group (most notably 1, 2, 12, and 13).

Keywords: antibacterial activity; green synthesis; imidazolium; ionic liquids; microwave irradiation; toxicity.

MeSH terms

Anti-Bacterial Agents* / chemical synthesis
Anti-Bacterial Agents* / chemistry
Anti-Bacterial Agents* / pharmacology
Bacteria / growth & development*
Dose-Response Relationship, Drug
Imidazoles* / chemistry
Imidazoles* / pharmacology
Ionic Liquids* / chemistry
Ionic Liquids* / pharmacology
Microwaves*

Substances

Anti-Bacterial Agents
Imidazoles
Ionic Liquids
imidazole