Striatal Microstructure and Its Relevance for Cognitive Control

Christian Beste; Christian K E Moll; Monika Pötter-Nerger; Alexander Münchau

doi:10.1016/j.tics.2018.06.007

Striatal Microstructure and Its Relevance for Cognitive Control

Trends Cogn Sci. 2018 Sep;22(9):747-751. doi: 10.1016/j.tics.2018.06.007. Epub 2018 Jul 14.

Authors

Christian Beste¹, Christian K E Moll², Monika Pötter-Nerger³, Alexander Münchau⁴

Affiliations

¹ Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Dresden, Germany. Electronic address: [email protected].
² Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
³ Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
⁴ Department of Pediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurogenetics, Center for Brain, Behavior and Metabolism, University of Lübeck, Germany. Electronic address: [email protected].

PMID: 30017252
DOI: 10.1016/j.tics.2018.06.007

Abstract

The relevance of the striatum for cognitive control processes is increasingly appreciated. The striatum is not a homogenous structure but instead is compartmentalized into the 'matrix' and 'striosomes'. Here, we discuss experiments on a model disease of striosomal dysfunction and provide evidence for the importance of the striatal microstructure for cognitive control in humans.

Keywords: basal ganglia; cognitive control; executive functions; striosomes.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cognition / physiology*
Corpus Striatum / anatomy & histology*
Corpus Striatum / physiology*
Corpus Striatum / physiopathology
Executive Function / physiology*
Humans
Self-Control