Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

Molecules. 2018 Jul 17;23(7):1751. doi: 10.3390/molecules23071751.

Abstract

In this narrative review, we have comprehensively reviewed the plant sources used as antiulcer agents. From traditional uses as herbal remedies, we have moved on to preclinical evidence, critically discussing the in vitro and in vivo studies focusing on plant extracts and even isolated phytochemicals with antiulcerogenic potential. A particular emphasis was also paid to Helicobacter pylori activity, with emphasis on involved mechanisms of action. Lastly, the issue of safety profile of these plant products has also been addressed.

Keywords: Helicobacter pylori; bioactive phytochemicals; gastric cancer; herbal remedies; peptic ulcer; traditional healing systems.

Publication types

  • Review

MeSH terms

  • Animals
  • Helicobacter Infections / drug therapy*
  • Helicobacter pylori*
  • Humans
  • Peptic Ulcer / drug therapy*
  • Peptic Ulcer / microbiology
  • Plant Extracts / chemistry*
  • Plant Extracts / therapeutic use*

Substances

  • Plant Extracts